Table 2.

Changes in mRNA Expression and Protein Levels in the Aging Retina and Choroid

	Retina		Choroid
mRNA	Protein	mRNA	Protein
iNOS	Decrease at 32 mo	Decrease at 32 mo	N/C	N/C
PGE2		Increase at 22 and 32 mo		Increase at 32 mo
PGE2-EP2		N/C		Increase at 32 mo
TNF-α	Increase at 32 mo	Decrease at 32 mo	Increase at 22 mo	Decrease at 22 mo

Note: iNOS = inducible nitric oxide synthase; mRNA = messenger RNA; N/C = not changed; PGE2 = prostaglandin E2; TNF-α = tumor necrosis factor alpha. Observed changes in mRNA gene expression and protein levels of the inflammatory markers investigated in the retina and choroid of Fischer 344 × Brown Norway F1 hybrid rats at 8, 22, and 32 months of age.