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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Oct 10;1792(1):68–74. doi: 10.1016/j.bbadis.2008.09.014

Figure 7.

Figure 7

Inter-relationships among complex I-mediated sPD cybrid respiration, complex I gene expression in sPD cybrids and sPD brains and levels of the 8 kDa complex I protein detected with the MS109 antibody from Mitosciences (see Supplemental Figure 1 and [22]). 7A shows the relationship in sPD cybrids between maximal complex I-mediated respiration and 8 kDa protein levels (normalized to mitofilin) in gradient-purified mitochondria from these cells; R=0.88). 7B shows the relationships among 8 kDa complex I protein levels in gradient-purified mitochondria from sPD brains and mtDNA-encoded complex I gene expression in the sPD brain samples; R varies from 0.78 to 0.88. 7C shows the relationship between mtDNA-encoded complex I gene relative expression in sPD cybrid cells compared to sPD brain. The outlier ND4 was not included in the regression analysis.