Table 1.

Current therapies for Alzheimer's disease.

Drug(s)	Proposed mechanism(s)	Status
Donepezil; galantamine; rivastigmine; tacrine	Increasing the neurotransmitter concentration at cholinergic synapses at many sites throughout the brain	US FDA-approved for the symptomatic treatment of mild and moderate AD; donepezil is also approved for use in severe AD
Memantine	Preventing glutamate excitotoxicity and/or stimulating dopamine receptors	FDA approved for the symptomatic treatment of moderate and severe AD

AD: Alzheimer's disease.