Table 2.

Performance Characteristics of the Method in Establishing or Excluding a Diagnosis of PH Defined as MPAP From RHC > 25 mm Hg

Criterion	Sensitivity (95% CI), %*	Specificity (95% CI), %*	PPV (95% CI), %*	NPV (95% CI), %*
Formula-predicted MPAP > 19 mm Hg	100 (66–100)	25 (13–41)	39 (13–41)	100 (66–100)
Formula-predicted MPAP > 21 mm Hg
Validation	95 (74–99)	58 (41–73)	51 (35–70)	96 (78–100)
Derivation, %†	100	40	50	100
Formula-predicted MPAP > 25 mm Hg
Validation	63 (38–84)	85 (70–94)	67 (36–86)	83 (63–89)
Derivation, %†	71	81	71	81
Formula-predicted MPAP > 35 mm Hg	21 (6–46)	100 (91–100)	100 (22–99)	73 (60–82)

^*PH was considered to be present when MPAP by RHC was > 25 mm Hg.

^†For comparison purposes, the performance of the predictor in the original derivation cohort is also listed.⁴