Table 2.

Effects of RTx on behavior in normal and PNT rats

		Licking behavior (Score)			Freezing behavior (Score)
Treatment	n	0–5	6–10	11–15 (Min)	0–5	6–10	11–15(Min)
Normal rats
Vehicle	5	6 [6–8]	1 [0–5]	2 [1–2]	0 [0–0]	0 [0–0]	0 [0–1]
RTx 3μM	5	33 [33–34]*	15 [14–20]*	5 [4–5]	8 [4–10]*	13 [12–14]**	10 [3–12]
PNT rats
Vehicle	6	4 [2–4]	2 [1–2]	2 [1–4]	0 [0–0]	0 [0–0]	0 [0–0]
RTx 3μM	5	12 [10–12]##	17 [16–24]**	13 [10–15]**	0 [0–2] #	10 [4–12]*	9 [4–27]**
PNT rats - Water unloaded
RTx 3μM	5	6 [5–8]	10 [10–12] $&	8 [3–9]$	0 [0–1]	3 [3–6] & &	4 [2–4] & &

The number (Score) of licking (A) or freezing behavior (B) was counted for each 5 min period (0–5, 5–10 or 10–15 min) after vehicle or RTx treatment in each rat. Each data represents the median value and interquartile range (in parentheses) obtained from 5–6 rats.

^*P<0.05,

^**P<0.01: compared to the vehicle group.

^#P<0.05,

^##P<0.01: compared to the RTx 3μM group in normal rats.

^$P<0.05: compared to the RTx 3μM group in PNT rats.

^&P<0.05,

^&&P<0.01: compared to the vehicle group in PNT rats. (Wilcoxon rank sum test)