Table 2.
CSF Concentrations of Immune Biomarkers
| Immune Measure (Median, IQR) | Control (n=12) | Interferon-alpha (n=12) | p-value1 |
|---|---|---|---|
| Cytokines (pg/ml) | |||
| IFN-alpha | 0 (0) | 0.34 (0.25) | 0.0001* |
| IL-6 | 1.64 (1.35) | 2.64 (1.71) | 0.005* |
| TNF-alpha† | -- | -- | |
| IL-1-beta† | -- | -- | |
| Chemokines (ng/ml) | |||
| MCP-1 | 371.55 (89.6) | 605.3 (296.8) | 0.0001* |
| Soluble Receptors (ng/ml) | |||
| sIL-6R | 0.76 (0.12) | 0.98 (0.44) | 0.03 |
| sTNF-R-2 | 0.26 (0.07) | 0.36 (0.19) | 0.07‡ |
IQR – Interquartile range
1
Exact Wilcoxon Rank Sum test;
*
indicates significance after adjustment for multiple comparisons as well as controlling for relevant covariates (see text)
†
TNF-alpha and IL-1 beta were not detectable in the majority of subjects
‡
sTNF-R-II exhhibited a significant difference between groups (p<0.01) after controlling for relevant covariates as well as controlling for multiple comparisons
IFN-interferon; IL-interleukin, TNF-tumor necrosis factor; MCP-1-monocytye chemoattractant protein 1; sIL-6R-soluble IL-6 receptor; sTNF-R-2-soluble TNF-alpha receptor 2