Table 3.
Plasma Concentrations of Immune Biomarkers
| Immune Measure (Median, IQR) | Control (n=12) | Interferon-alpha (n=12) | p-value1 |
|---|---|---|---|
| Cytokines (pg/ml) | |||
| IFN-alpha | 4.65 (8.35) | 37.85 (40.16) | 0.0001* |
| IL-6 | 3.67 (2.1) | 3.17 (1.5) | 0.48 |
| TNF-alpha | 1.46 (1.22) | 1.77 (1.90) | 0.75 |
| IL-1 beta† | -- | -- | |
| Chemokines (ng/ml) | |||
| MCP-1 | 225.0 (142.5) | 365.5 (132.0) | 0.005* |
| Soluble Receptors (ng/ml) | |||
| sIL-6R | 33.38 (9.7) | 28.95 (10.5) | 0.51 |
| sTNF-R-2 | 2.05 (1.89) | 2.84 (0.96) | 0.09 |
IQR – Interquartile range
1
Exact Wilcoxon Rank Sum test;
*
indicates significance after adjustment for multiple comparisons
†
IL-1 beta were not detectable in the majority of subjects
IFN-interferon; IL-interleukin, TNF-tumor necrosis factor; MCP-1-monocytye chemoattractant protein 1; sIL-6R-soluble IL-6 receptor; sTNF-R-2-soluble TNF-alpha receptor 2