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. 2009 Jan 30;2(5):433–443.

Figure 2.

Figure 2

PSAPP/Tat mice receiving oral dox show increased A-beta plaques compared to PSAPP mice. A. Mouse brain coronal frozen sections were stained with rabbit polyclonal anti-human A antibody. Left column indicates PSAPP mice receiving dox, middle column indicates PSAPP/Tat mice without dox and right column indicates PSAPP/Tat mice receiving dox. As indicated, the top panels are from the cingulate cortex (CC), the middle panels are from the hippocampus (H), and bottom panels are from the entorhinal cortex (EC). B. Percentages of A antibody-immunoreactive A plaque (mean ± SD) were calculated by quantitative image analysis. C. Soluble A1-40, 42 (left) and insoluble A-beta1-40, 42 (right) prepared with 5 M guanidine were analyzed by ELISA. Data are presented as (pg/mg protein) of A1-40 or A1-42 separately.