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. 2009 Jan 30;2(5):433–443.

Figure 3.

Figure 3

Figure 3

PSAPP/Tat mice receiving oral dox show increased neuronal degeneration and tau-phosphorylation after oral administration of dox compared to PSAPP mice. Left column indicates PSAPP mice receiving dox, middle column indicates PSAPP/Tat mice without dox and right column indicates PSAPP/Tat mice receiving dox. Mouse brain coronal frozen sections were stained with H&E (A) or with phospho-tau antibody (AT270) (B). PSAPP/Tat mice receiving oral dox show increased neuronal degeneration and tau-phosphorylation after oral administration of dox compared to PSAPP mice. Mouse brain homogenates were prepared from these mice and subjected to Western blot analysis for Bcl-xL, Bax; and phosphor-Tau. Compared to PSAPP mice receiving dox or PSAPP/Tat mice without dox, PSAPP/Tat mice receiving dox demonstrate a significantly increased ratio of Bax to Bcl-xL (C) as well as Tau protein (phospho-AT270) to actin ratio by densitometry analyses (D).