Table 3.
Comparison of HER2/neu status in ESC as determined by IHC and fluorescent in situ hybridization
| References | Santin et al [106] | Odicino et al [108] | Slomovitz et al[107] | Villella et al[105] | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IHC score | 0–1+ | 2+ | 3+ | 0–1+ | 2+ | 3+ | 0–1+ | 2+ | 3+ | 0–1+ | 2+ | 3+ |
| Cases (N)* | 13** | 7 | 9 | 10 | 0 | 2 | 56 | 10 | 2 | 6 | 0 | 3 |
| Amplified | 0 | 2 | 9 | 0 | NA | 2 | NP | 1 | 1 | 1 | NA | 3 |
| Not amplified | 13 | 5 | 0 | 10 | NA | 0 | NP | 9 | 1 | 5 | NA | 0 |
*
Successful hybridizations;
**
as outlined in original report; NA, not applicable; NP, FISH not performed; IHC, immunohistochemistry