Table 2.

Specific susceptibility genes in type 1 and type 2 autoimmune hepatitis

Genes	Population	Type of AIH	Linkage disequilibrium	References
MHC genes
HLA-A1-B8	North-America, Europe	1	Yes	[14,15]
HLA-DRB1*0301	North-America, UK, Spain, Argentina	1 and 2	Yes	[14,15,25]
HLA-DRB1*0401	North-America, Europe		ND	[14,15]
HLA-DRB1*0404	Mexico	1	ND	[18]
HLA-DRB1*0405	Argentina, Japan	1	-	[19,20]
HLA-DRB1*1301	North-America, Europe, Brazil, Argentina	1	Yes	[16,21]
HLA-DRB1-07	Germany, Brazil, UK	2	Yes	[23,24]
HLA-DRB3*01	Brazil			[22,23]
HLA-DQB1*0201	North-America, Europe	2	Yes	[16]
HLA-DQB1*0603	North-America, Europe	2	Yes	[16]
Non-MHC genes
IgA	Europe	1		[28,29]
C4A	Europe, North-America	1 and 2	Yes	[30,31]
CTLA4	North-America, Europe	1	Yes	[35,36]
Fas	Japan, North-America	1	ND	[37,38]
Vitamin D receptor	Germany	1 and 2	ND	[39]
TNFa*2	North-America, UK	1	Yes	[43,44]

ND: Non-determined.