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Both TTX and LS depressed the amplitude of recurrent monosynaptic connections between layer 2/3 pyramidal neurons. A, Examples of evoked recurrent EPSCs in response to the firing of presynaptic neurons at 20 Hz in control, LS, and TTX conditions. B, Average EPSC amplitude (Amp; in picoamperes), paired-pulse ratio (PP ratio), CV, and failure rates (% failures) for control (black bar), LS (white bar), and TTX (gray bar) conditions. *Significantly different from control.
