Table 2.
Tests for treatment-by-SNP interaction effect on 7-day point prevalence of smoking cessation at end of treatment, SNPs on randomly selected genes.
| Percent Abstinent at EOT (# of subjects) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP=0 | SNP=1 | |||||||||
| Rank | RS Number | Gene | Bayes Factor | LRT p | Adjusted LRT p | Prevalence, SNP=1 (%) | Placebo | Bupropion | Placebo | Bupropion |
| 1 | rs2839290 | DIP2A | 0.656 | 0.208 | 1.000 | 22.4 | 22(141) | 29(177) | 20(51) | 41(41) |
| 2 | rs638732 | VGCNL1 | 0.699 | 0.159 | 0.999 | 63.4 | 18(76) | 36(74) | 24(118) | 29(142) |
| 3 | rs741441 | MGC35440 | 0.728 | 0.041 | 0.850 | 71.3 | 31(58) | 29(63) | 17(140) | 33(160) |
| 4 | rs2828759 | Unidentified | 0.758 | 0.055 | 0.920 | 64.4 | 28(79) | 29(69) | 17(118) | 35(150) |
| 5 | rs256875 | Unidentified | 0.832 | 0.176 | 1.000 | 23.2 | 25(139) | 34(152) | 13(38) | 34(50) |
| 6 | rs2750097 | Unidentified | 0.865 | 0.244 | 1.000 | 66.5 | 17(76) | 35(63) | 24(119) | 31(157) |
| 7 | rs1909118 | NFLA | 0.908 | 0.256 | 1.000 | 25.6 | 23(145) | 30(158) | 14(49) | 31(55) |
| 8 | rs1024766 | Unidentified | 0.940 | 0.281 | 1.000 | 68.6 | 19(47) | 36(58) | 25(110) | 30(119) |
| 9 | rs588981 | UNC93A | 0.953 | 0.196 | 1.000 | 58.4 | 15(87) | 32(85) | 27(108) | 35(133) |
| 10 | rs1910412 | LASS3 | 0.968 | 0.086 | 0.976 | 71.6 | 30(57) | 30(61) | 18(137) | 34(160) |
| 11 | rs1467200 | GRK7 | 1.072 | 0.306 | 1.000 | 36.6 | 22(125) | 29(143) | 20(74) | 37(81) |
| 12 | rs907444 | Unidentified | 1.094 | 0.206 | 1.000 | 35.8 | 25(103) | 35(127) | 11(62) | 29(66) |
| 13 | rs1691251 | AHCTF1 | 1.102 | 0.437 | 1.000 | 74.4 | 23(43) | 41(59) | 22(146) | 30(151) |
| 14 | rs2611611 | Unidentified | 1.127 | 0.320 | 1.000 | 56.3 | 20(88) | 37(93) | 23(105) | 30(128) |
| 15 | rs2009866 | EFCAB3 | 1.244 | 0.579 | 1.000 | 21.7 | 22(152) | 32(179) | 20(46) | 35(46) |
| 16 | rs1534596 | FMN1 | 1.245 | 0.378 | 1.000 | 62.0 | 17(80) | 33(80) | 25(118) | 33(143) |
| 17 | rs1468158 | Unidentified | 1.312 | 0.298 | 1.000 | 49.9 | 26(101) | 34(107) | 16(94) | 31(113) |
| 18 | rs736737 | CCDC105 | 1.417 | 0.429 | 1.000 | 47.6 | 26(99) | 33(120) | 17(98) | 30(101) |
| 19 | rs2031633 | ZC3H13 | 1.433 | 0.409 | 1.000 | 46.2 | 26(108) | 34(120) | 17(90) | 30(106) |
| 20 | rs2054213 | SETD1A | 1.452 | 0.459 | 1.000 | 45.5 | 21(108) | 28(116) | 21(87) | 35(100) |
| 21 | rs1330106 | LOC728727 | 1.452 | 0.459 | 1.000 | 45.5 | 21(108) | 28(116) | 21(87) | 35(100) |
| 22 | rs1939810 | KIAA1826 | 1.488 | 0.466 | 1.000 | 61.8 | 22(68) | 28(93) | 22(129) | 35(132) |
| 23 | rs878451 | LOC152485 | 1.502 | 0.540 | 1.000 | 50.8 | 21(85) | 31(97) | 20(85) | 36(103) |
| 24 | rs1365057 | Unidentified | 1.529 | 0.449 | 1.000 | 42.5 | 26(121) | 36(120) | 14(76) | 27(102) |
| 25 | rs2036943 | Unidentified | 1.531 | 0.624 | 1.000 | 50.4 | 20(89) | 34(93) | 22(85) | 32(100) |
| 26 | rs2208056 | C20orf23 | 1.567 | 0.604 | 1.000 | 59.3 | 22(76) | 30(93) | 21(120) | 33(126) |
| 27 | rs2190184 | Unidentified | 1.581 | 0.521 | 1.000 | 46.5 | 25(100) | 33(121) | 17(93) | 29(99) |
| 28 | rs2054255 | NUDCD1 | 1.637 | 0.543 | 1.000 | 58.8 | 22(86) | 30(88) | 21(110) | 34(138) |
| 29 | rs1885423 | Unidentified | 1.650 | 0.978 | 1.000 | 66.1 | 20(64) | 30(79) | 23(133) | 34(146) |
| 30 | rs1906810 | Unidentified | 1.653 | 0.877 | 1.000 | 66.4 | 24(62) | 35(78) | 20(133) | 31(144) |
| 31 | rs136501 | Unidentified | 1.670 | 0.667 | 1.000 | 30.2 | 20(142) | 32(151) | 24(55) | 32(72) |
| 32 | rs2052584 | PHLPPL | 1.686 | 0.787 | 1.000 | 29.7 | 22(140) | 34(154) | 22(55) | 30(69) |
| 33 | rs829864 | Unidentified | 1.688 | 0.993 | 1.000 | 65.8 | 23(66) | 34(77) | 21(131) | 32(144) |
| 34 | rs2294693 | UNC5CL | 1.703 | 0.737 | 1.000 | 42.0 | 19(109) | 31(137) | 24(89) | 34(89) |
| 35 | rs719674 | Unidentified | 1.705 | 0.667 | 1.000 | 63.5 | 27(74) | 37(79) | 18(123) | 29(143) |
| 36 | rs288259 | DNAJC10 | 1.717 | 0.937 | 1.000 | 57.8 | 22(82) | 31(80) | 21(101) | 31(121) |
| 37 | rs1106499 | ZNF445 | 1.721 | 0.862 | 1.000 | 53.0 | 24(90) | 35(106) | 19(104) | 30(117) |
| 38 | rs2605141 | SMCR7 | 1.735 | 0.918 | 1.000 | 56.5 | 22(78) | 34(105) | 20(119) | 31(119) |
| 39 | rs1359719 | Unidentified | 1.740 | 0.992 | 1.000 | 48.0 | 21(104) | 31(115) | 23(93) | 33(109) |
| 40 | rs2598108 | EPDR1 | 1.753 | 0.871 | 1.000 | 58.3 | 20(83) | 31(89) | 21(112) | 34(128) |
| 41 | rs2802853 | NFASC | 1.758 | 0.976 | 1.000 | 58.9 | 21(85) | 33(85) | 22(111) | 34(133) |
| 42 | rs946778 | ZFYVE27 | 1.762 | 0.835 | 1.000 | 45.3 | 18(103) | 29(126) | 26(94) | 36(96) |
| 43 | rs1998505 | CEP110 | 1.766 | 0.987 | 1.000 | 52.2 | 18(88) | 28(112) | 25(106) | 36(112) |