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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Cancer Res. 2009 Feb 3;69(4):1509–1516. doi: 10.1158/0008-5472.CAN-08-3133

Figure 4.

Figure 4

OM137 inhibits Aurora kinases. (A) Assay for OM137 inhibition of Aurora A (left) and Aurora B (right) kinases. For Aurora A IC50 = 21.7 µM and for Aurora B IC50 = 2.4 µM. B, OM137 at 10 µM does not inhibit other mitotic kinases: Mps1, Bub1, Plk1, Nek2A and Tao1. Brackets denote test substrates for each kinase (see Methods). C, OM137 shows inhibition of Cdk1/CyclinB and Cdk5/p25 in vitro. Error bars indicate S.D.