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Overexpression of wild-type SCAMP3 but not a double mutant inhibits EGF degradation and increases recycling. HeLa were transfected with vector (pcDNA 3.1), wild-type mouse SCAMP3, or DM-SCAMP3. (A) Degradation of 125I-EGF. (B) Recycling of 125I-EGF. Error bars, SEM, determined from three separate experiments.
