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. Author manuscript; available in PMC: 2009 Apr 24.
Published in final edited form as: J Med Chem. 2008 Mar 12;51(8):2502–2511. doi: 10.1021/jm701500e

Table 5.

Selection of Compounds Screened with Reactive Functional Groupsa

Functional Group Structure Screened Hits
2-halopyridine graphic file with name nihms86140t33.jpg 50 0
4-halopyridine graphic file with name nihms86140t34.jpg 13 0
Sulfonyl halide graphic file with name nihms86140t35.jpg 5 0
aldehyde graphic file with name nihms86140t36.jpg 32 0
alkyl halide graphic file with name nihms86140t37.jpg 84 0
acid halide graphic file with name nihms86140t38.jpg 6 0
iso(thio)cyanate –NCO(S) 10 0
epoxide, aziridine, thioepoxide graphic file with name nihms86140t39.jpg 110 0
michael acceptor graphic file with name nihms86140t40.jpg 289 3
dihydroxybenzene graphic file with name nihms86140t41.jpg 31 0
anhydride graphic file with name nihms86140t42.jpg 6 0
aromatic azide graphic file with name nihms86140t43.jpg 5 0
tritrihydroxylphenyl graphic file with name nihms86140t44.jpg 12 0
a

Full list of functional groups searched is given in Supporting Information, Table 4.