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. Author manuscript; available in PMC: 2009 Mar 14.
Published in final edited form as: J Comp Neurol. 2006 Feb 1;494(4):578–594. doi: 10.1002/cne.20827

Fig. 6.

Fig. 6

Time-course of CNS macrophage activation is similar between all strains but is dramatically reduced in magnitude in BALB/c mice (A; n=3–6/time/strain except 42 dpi C57BL/6 where n=9; *, **, ***p<0.05, 0.01 or 0.001, respectively vs. C57BL/6). Macrophage activation in acutely injured spinal cord (3dpi) is most prevalent within central spinal cord gray matter (shown for C57BL/6 (B) and BALB/c (C) mice). Peak macrophage activation occurs 7–14dpi with large rounded CD11b+ macrophages occupying most of the cross-sectional area at the impact site (only 7dpi shown; D&E). By 42dpi, an intense CNS macrophage response persists in all strains except BALB/c mice [C57BL/6 (F); BALB/c (G)]. Scale = B–G (400 μm), high-power inserts of boxed regions (100 μm).