Table 1.
General and laboratory parameters in samples of control (C), ANGII-treated control (CA), 7 week streptozotocin-diabetic (D7), and ANGII-treated D7 (D7A) rats
| C | CA | D7 | D7A | |
|---|---|---|---|---|
| Body weight (g) | 390 ± 37 | 393 ± 42 | 280 ± 32+ | 273 ± 38++ |
| Kidney weight (g) | 1.9 ± 0.4 | 1.8 ± 0.4 | 2.0 ± 0.4 | 2 ± 0.4 |
| Kidney/body weight | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.7 ± 0.3+ | 0.7 ± 0.4++ |
| Non-fasting blood glucose (mm l−1) | 8.6 ± 1.4 | 8.2 ± 1.7 | 30.9 ± 2.5+ | 27.9 ± 3.2++ |
| Fructosamine (μm l−1) | 137 ± 4 | 143 ± 4 | 252 ± 8+ | 265 ± 32++ |
| Serum sodium (mm l−1) | 149 ± 7 | 142 ± 4 | 145 ± 10 | 143 ± 8 |
| Serum potassium (mm l−1) | 4.7 ± 0.1 | 4.9 ± 0.2 | 4.9 ± 0.7 | 5.5 ± 0.6++ |
| Serum creatinine (μm l−1) | 68 ± 5 | 65 ± 2 | 81 ± 10+ | 97 ± 5++ |
| Blood urea nitrogen (mm l−1) | 4.7 ± 0.3 | 7.5 ± 1.3* | 10 ± 1.9+** | 21 ± 3.0++ |
| Urinary sodium (mm l−1) | 69 ± 11 | 55 ± 27 | 35 ± 8+** | 13 ± 1++ |
| Urinary potassium (mm l−1) | 38 ± 17 | 35 ± 30 | 16 ± 7 | 22 ± 3 |
| Urinary creatinine (μm l−1) | 1156 ± 231 | 573 ± 300* | 285 ± 173+** | 175 ± 96++ |
| Urinary urea nitrogen (mm l−1) | 83 ± 44 | 95 ± 63 | 69 ± 22** | 181 ± 26++ |
| Fractional sodium excretion (%) | 2.8 ± 0.6 | 4.5 ± 0.3* | 8.1 ± 0.3+ | 6.3 ± 0.3++ |
| Mean arterial pressure (mmHg) | 98.7 ± 1.7 | 125.2 ± 2.4* | 100.7 ± 1.6 | 109.1 ± 5.3 |
n = 6 per group.
*
P < 0.05, C vs CA;
**
P < 0.05, D7 vs D7A;
+
P < 0.05, C vs D7;
++
P < 0.05, CA vs D7A.