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. 2008 Oct 2;586(Pt 22):5487–5502. doi: 10.1113/jphysiol.2008.156224

Figure 5. Responses driven by the ON cone bipolar cell/AII amacrine cell pathway adapt by reducing gain only.

Figure 5

A and B, linear filters and nonlinearities measured at Vhold=−44 mV under a control condition and in the presence of bath-applied iGluR antagonists (200 μm CNQX and 200 μm d-AP-5). The initial 200 ms of the linear filter is shown on an expanded scale at right. The zero-crossing of the filter (arrow) was reduced at high contrast in the control condition but not in the CNQX/d-AP-5 condition. The reduced gain at high contrast was larger in the CNQX/d-AP-5 condition (0.55) relative to the control condition (0.72). The blockers had two effects on filter kinetics: increased oscillation and removal of the contrast-dependent shortening of integration time. C, relative gain for control and CNQX/d-AP-5 conditions (n = 9 cells). Vhold was −48 ± 4 mV (mean ±s.d.). The gain change was larger in the CNQX/d-AP-5 condition. D, relative zero-crossing time for the control and CNQX/d-AP-5 conditions. The contrast-dependent change in the zero-cross time was removed in the presence of CNQX and d-AP-5. The absolute zchigh was 84 ± 4 ms for the control condition and 90 ± 3 ms for the CNQX/d-AP-5 condition (n = 9).