Figure 8. Retigabine completely abolished intrinsic bursts in both neonatal and juvenile neurons.

A, intrinsic bursting activity recorded from a CA3 principal cell at P6 before (Control) 2 min and 4 min after bath application of 10 μm retigabine (Retigabine) and after addition of 10 μm linopirdine to retigabine (+Linopirdine). B, as in A but from a CA3 principal neuron at P17. Note that in both cases, retigabine first reduced the frequency and the duration of intrinsic bursts and then completely abolished them. Intrinsic bursting activity could be restored by adding linopirdine to the bathing solution.