Table 1.
Voltage-gated proton channel (HVCN1) family
| GeneID | Protein identity (%) | Gene aliases | Organism | MW | Length (AA) |
|---|---|---|---|---|---|
| 84329 | 100 | VSOP, MGC15619, UNQ578/PRO1140 | Homo sapiens (Human) | 31 683 | 273 |
| 709745 | 93.4 | LOC709745 | Macaca mulatta (rhesus monkey) | 31 523 | 273 |
| 616570 | 86.2 | – | Bos taurus (cow) | 31 872 | 272 |
| 608547 | 85.3 | – | Canis lupus familiaris (dog) | 31 216 | 268 |
| 74096 | 78.0 | BTS, VSOP, 0610039P13Rik, AI450555 | Mus musculus (mouse) | 31 242 | 269 |
| 416871 | 53.5 | RCJMB04–1c7 | Gallus gallus (chicken) | 27 599 | 235 |
| 496712 | 45.6 | — | Xenopus (Silurana) tropicalis (western clawed frog) | 26 575 | 230 |
| 496219 | 43.6 | — | Xenopus laevis (African clawed frog) | 26 596 | 230 |
| 436618 | 40.9 | zgc:92181 | Danio (Brachydanio) rerio (zebrafish) | 27 110 | 235 |
| 778897 | 26.1 | VSOP, VSX1 | Ciona intestinalis(transparent sea squirt) | 38 501 | 342 |
| 586317 | 22.3 | VSOP | Strongylocentrotus purpuratus(purple sea urchin) | 37 483 | 328 |
Characteristics of proteins coded by selected proton channel genes. Species for which the expressed gene product has been demonstrated by voltage clamp to function as a proton channel are in bold: human (Ramsey et al. 2006), mouse and Ciona (Sasaki et al. 2006), and sea urchin (personal communication, Y. Okamura). VSOP, voltage sensor domain-only protein. Identity with the human protein is from EMBL-EBI (http://www.ebi.ac.uk/Tools/es/cgi-bin/jobresults.cgi/needle). Some aliases are from UniProt (http://www.uniprot.org/). The isotopically averaged molecular weight (MW) of a monomer is given using Protein Calculator v. 3.3 (http://www.scripps.edu).