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. 2008 Oct 2;586(Pt 23):5665–5678. doi: 10.1113/jphysiol.2008.161943

Figure 2.

Figure 2

Presence of GABAAR-mediated tonic inward conductance at P19–34, but not P7–14 A, sample trace to illustrate that at P12–14 the mean holding current (indicated by white dashed lines) was only marginally affected by bicuculline methiodide (BMI, 20 μm). Also note that in the presence of ionotropic glutamate receptor antagonists sIPSCs were completely blocked by BMI. In all voltage-clamp experiments the holding potential was set to –70 mV. B, all-point histograms constructed from representative 10 s periods in the absence and in the presence of BMI (as indicated by encircled numbers). Thick lines represent Gaussian fits. C, quantification of results. Note that in this set of experiments the high Cl− intrapipette solution was used. D, membrane resistance was not affected by BMI. E, sample trace to illustrate that at P19–21 application of BMI produced distinct tonic outward currents. F, all-point histograms constructed from representative 10 s periods in the absence and in the presence of BMI (as indicated by encircled numbers). Thick lines represent Gaussian fits. G, quantification of results. H, lack of changes in membrane resistance. I, up-regulation of tonic GABAAR-mediated inward conductance during striatal development. Quantification of results. ns – not significant, *P < 0.05, **P < 0.01.