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. 2008 Oct 20;586(Pt 24):5885–5900. doi: 10.1113/jphysiol.2008.163469

Figure 7. PSD-95 and PSD-93 have unique roles in pairing-induced LTP.

Figure 7

A, pairing EPSPs elicited by a 10-Hz train of presynaptic fibre stimulation with single postsynaptic action potentials failed to induce LTP in wild-type cells (○, n = 13 cells from 9 mice) and PSD-93−/− cells (▲, n = 8 cells from 4 mice) but induced robust LTP in PSD-95 mutant cells (•, n = 7 cells from 6 mice). Results were the same in cells from PSD-93 and PSD-95 wild-type littermates and were therefore combined (n = 7 cells from 4 mice and 6 cells from 5 mice, respectively). The inset shows superimposed EPSPs recorded during baseline and 30 min post-pairing in a wild-type (left), PSD-95 (middle) and PSD-93 mutant cell (right). Calibration bars are 15 ms and 5 mV. B, cumulative probability distribution plot showing the amount of potentiation present 30 min post-pairing in wild-type (○) as well as PSD-93 (▲) and PSD-95 (•) mutant cells in experiments where EPSPs were paired with single postsynaptic action potentials. C, pairing EPSPs elicited during a 10 Hz train of presynaptic fibre stimulation with a burst of postsynaptic action potentials induces similar amounts of LTP in wild-type (○, n = 14 cells from 9 mice) and PSD-95 mutant cells (•, n = 7 cells from 5 mice). In contrast, the induction of LTP by EPSPs paired with bursts of postsynaptic action potentials was disrupted in PSD-93−/− cells (▲, n = 9 cells from 4 mice). Results from wild-type littermates were the same and were therefore combined (n = 8 cells from 4 PSD-93 wild-type littermates and 5 cells from 4 PSD-95 wild-type littermates). The inset shows superimposed EPSPs recorded during baseline and 30 min post-pairing in a wild-type (left), PSD-95 (middle) and PSD-93 mutant cell (right). Calibration bars are 15 ms and 5 mV. D, cumulative probability distribution plot showing the amount of potentiation present 30 min post-pairing in wild-type (○), PSD-93 mutant (▲) and PSD-95 mutant cells (•) in experiments where EPSPs were paired with a burst of postsynaptic action potentials.