Table 3.
Skeletal muscle morphology and capillarization in the gastrocnemius in untrained and exercise-trained muscle of WT and AMPK DN mice
| Untrained | Exercise trained | P value | |||||
|---|---|---|---|---|---|---|---|
| WT (n = 8) | AMPK DN (n = 9) | WT (n = 8) | AMPK DN (n = 10) | Interaction | Transgene | Exercise | |
| Capillary contacts | 4.03 ± 0.17 | 3.09 ± 0.23 † | 4.12 ± 0.37 | 4.25 ± 0.20 | 0.03 | — | — |
| Capillary-to-fibre ratio | 1.35 ± 0.07 | 1.04 ± 0.09 † | 1.42 ± 0.12 | 1.46 ± 0.07 | 0.05 | — | — |
| Capillary density (capillaries mm−2) | 708 ± 68 | 605 ± 94 | 796 ± 95 | 699 ± 25 | 0.97 | 0.19 | 0.22 |
| CFPE (capillaries (1000 mm)−1) | 7.15 ± 0.45 | 5.86 ± 0.65 | 7.68 ± 0.63 | 7.44 ± 0.27 | 0.31 | 0.15 | 0.05 |
| Fibre area (μm2) | 2167 ± 152 | 2113 ± 203 | 2207 ± 195 | 2356 ± 118 | 0.55 | 0.78 | 0.41 |
| Fibre perimeter (μm) | 194 ± 7 | 187 ± 9 | 193 ± 10 | 201 ± 4 | 0.33 | 0.94 | 0.42 |
| Fibre-type composition (%) | |||||||
| Type IIb | 100 | 100 | 100 | 100 | |||
Data are mean ± s.e.m. CFPE, capillary-to-fibre perimeter exchange index.
†
Significantly different from all other groups.