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Upper panels show end-tidal partial pressures of oxygen (
) and carbon dioxide (
) during acute hypoxic challenges. Lower panels show corresponding measurements of pulmonary artery systolic pressure (PASP). DFO denotes desferrioxamine. Values are means and error bars indicate s.e.m. Infusion of DFO increased PASP (P < 0.001) and sensitized the pulmonary vascular response to acute hypoxia (P = 0.01).
