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. 2008 Nov 10;586(Pt 24):5969–5982. doi: 10.1113/jphysiol.2008.159715

Figure 3. Release probability does not change significantly between 25° C and 35 °C.

Figure 3

A and B, fractional release at 25°C. Sample traces from a single synapse (A); the average response to a single AP is shown in black (n = 19) and the response to 40 APs at 20 Hz in grey. The ratio between the two peaks provides a measure of the intrinsic release probability of a vesicle in the readily releasable pool (RRP). Intrinsic release probabilities from 79 synapses are plotted in the histogram in B, the average value is 0.095 ± 0.008. Continuous grey line is a γ distribution with shape parameter constrained to 2, giving the scale parameter 0.048 ± 0.002. C and D, fractional release at 35°C. Sample traces are shown in C and histogram of intrinsic release probabilities in D. The average was 0.076 ± 0.008. Black line is a γ distribution with shape parameter constrained to 2 and scale parameter 0.037 ± 0.001. No significant difference between the two temperatures as judged by Kolmogorov–Smirnov test (P = 0.59).