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. 2008 Dec 19;191(7):2144–2152. doi: 10.1128/JB.01487-08

TABLE 2.

Complete list of membrane-associated proteins identified by Protein Biomarker Discovery Service

NCBI RefSeq accession no. Protein characteristic(s)a
NP_872672.1 Major OM protein homolog, OmpA2
NP_873123.1 Lipoprotein Hlp
NP_872671.1 Major OM protein
NP_872802.1 Periplasmic zinc transporter
NP_873651.1 Hypothetical OM protein
NP_873192.1 30S ribosomal protein S7b
NP_872695.1 Periplasmic nitrate reductaseb
NP_873124.1 Lipoprotein HlpBb
NP_874240.1 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA
NP_874283.1 30S ribosomal protein S4b
NP_872858.1 15-kDa OM lipoproteinb
NP_872909.1 Manganese superoxide dismutase
NP_874147.1 60-kDa chaperonin
NP_873267.1 Endo-1,4-beta-xylanase Ab
NP_873991.1 30S ribosomal protein S2
NP_873158.1 Heme binding protein
NP_873136.1 Hypothetical protein HD0595b
NP_872850.1 Hypothetical protein HD0256
NP_874290.1 30S ribosomal protein S5b
NP_873316.1 Hypothetical protein HD0805b
NP_873652.1 OM protein D-15
NP_874221.1 50S ribosomal protein L7/L12
NP_874308.1 50S ribosomal protein L2b
NP_873552.1 Spermidine/putrescine-binding periplasmic protein
NP_874222.1 50S ribosomal protein L10
NP_873987.1 Ribosome releasing factor
NP_874254.1 Collagen adhesin NcaA
NP_874343.1 Hemoglobin-binding protein HgbA
NP_873635.1 OM protein P4
NP_872793.1 Chaperone protein DnaK
NP_874312.1 30S ribosomal protein S10b
NP_873494.1 DNA-binding protein HUb
NP_873733.1 Tight adherence protein Db
NP_874137.1 18,000-molecular-weight peptidoglycan-associated OM lipoprotein PAL
NP_873827.1 Hypothetical protein HD1409b
NP_874224.1 50S ribosomal protein L11b
NP_873538.1 Nucleoside diphosphate kinase
NP_874163.1 Translation initiation factor IF3b
NP_873902.1 30S ribosomal protein S9
NP_873019.1 Pyruvate kinase II
NP_873133.1 Hypothetical protein HD0591b
NP_873623.1 Large supernatant protein 2b
NP_873911.1 Large supernatant protein 1b
NP_874292.1 50S ribosomal protein L6b
NP_872899.1 Transaldolase
NP_874286.1 50S ribosomal protein L36b
NP_873852.1 OM protein P2 homolog
NP_874288.1 50S ribosomal protein L15b
NP_872690.1 Fine tangled pili major subunit
NP_872796.1 Hypothetical protein HD0192b
NP_874256.1 DNA-directed RNA polymerase omega subunitb
NP_873235.1 3-Oxoacyl-(acyl-carrier-protein) reductase, truncated
NP_872807.1 50S ribosomal protein L27b
NP_873584.1 Dihydrodipicolinate synthaseb
NP_874160.1 Hypothetical protein HD1798b
NP_873288.1 50S ribosomal protein L32b
NP_873671.1 Hypothetical protein HD1218b
NP_872936.1 Heat shock protein HtpXb
NP_873637.1 RNA polymerase sigma-70 factorb
NP_873668.1 Small protein Ab
NP_873029.1 Hypothetical protein HD0457b
NP_873262.1 RNA-binding protein Hfqb
NP_874092.1 50S ribosomal protein L31b
NP_874225.1 Transcription antitermination protein NusG
NP_874223.1 50S ribosomal protein L1
NP_873210.1 Hypothetical protein HD0680
NP_874284.1 30S ribosomal protein S11b
NP_872663.1 Coproporphyrinogen III oxidaseb
NP_872680.1 Elongation factor Tu
NP_873194.1 Elongation factor Tu
NP_874042.1 Phosphoglyceromutase
NP_874291.1 50S ribosomal protein L18b
NP_874280.1 30S ribosomal protein S16b
NP_872641.1 ATP synthase subunit Bb
NP_873551.1 HSP-70 cofactor
NP_873350.1 Superoxide dismutase [Cu-Zn]b
NP_873801.1 Hypothetical protein HD1377b
NP_872827.1 Phosphotransferase system phosphocarrier protein HPrb
NP_873040.1 Conserved putative lipoproteinb
NP_873191.1 30S ribosomal protein S12b
NP_873285.1 Serum resistance protein DsrA
NP_873532.1 30S ribosomal protein S18b
NP_873221.1 RNA polymerase sigma factorb
NP_874075.1 Organic solvent tolerance protein precursorb
NP_873197.1 Export protein SecB
NP_873277.1 Lipoproteinb
NP_873102.1 Aminopeptidase A/Ib
NP_873292.1 Hypothetical protein HD0776b
NP_874344.1 Large-conductance mechanosensitive channelb
NP_872854.1 Periplasmic serine protease do
NP_874177.1 Iron (chelated) ABC transporter, periplasmic-binding protein
NP_873279.1 Acid phosphatase stationary-phase survival proteinb
NP_874108.1 Putative uroporphyrinogen III C-methyltransferaseb
NP_872940.1 Hypothetical protein HD0358b
NP_874148.1 Co-chaperonin GroES
NP_874289.1 50S ribosomal protein L30b
NP_874140.1 Colicin transport protein, TolQb
NP_874120.1 Ferritin-like protein 1
NP_874012.1 Dihydrolipoamide acetyltransferase
NP_873182.1 Hypothetical protein HD0646b
NP_873496.1 Hypothetical protein HD1006b
NP_873530.1 30S ribosomal protein S6
NP_874117.1 Preprotein translocase subunit YajCb
NP_874285.1 30S ribosomal protein S13b
NP_872698.1 Possible cytochrome c-type proteinb
NP_872785.1 3-Hydroxydecanoyl-acyl carrier protein dehydrataseb
NP_873254.1 50S ribosomal protein L28b
NP_873904.1 Hypothetical protein HD1495b
NP_874263.1 Acyl carrier protein
NP_873249.1 Hypothetical protein HD0725b
NP_874191.1 Xanthine phosphoribosyltransferaseb
NP_873669.1 Hypothetical protein HD1215b
NP_873895.1 Integration host factor, alpha chainb
NP_874296.1 50S ribosomal protein L24b
NP_873876.1 Translation initiation factor IF2b
NP_872806.1 50S ribosomal protein L21b
NP_873499.1 Putative solute/DNA competence effectorb
NP_874282.1 DNA-directed RNA polymerase alpha subunit
NP_874327.1 Hypothetical protein HD2003
NP_874111.1 ABC-type transport protein Uupb
NP_873974.1 Condensin subunit B
NP_874219.1 DNA-directed RNA polymerase beta subunitb
NP_873097.1 5"-Phosphoribosylglycinamide transformylaseb
NP_873358.1 2-Dehydro-3-deoxyphosphooctonate aldolaseb
NP_873559.1 Cysteine desulfurase
NP_873624.1 Anaerobic glycerol-3-phosphate dehydrogenase, subunit Ab
NP_873795.1 Hypothetical protein HD1371b
NP_873981.1 ATP-dependent RNA helicaseb
NP_874039.1 Hypothetical protein HD1654b
NP_874114.1 DNA gyrase subunit Ab
NP_872657.1 Fumarate reductase
NP_872776.1 Dinucleoside polyphosphate hydrolaseb
NP_872798.1 RNase Eb
NP_873314.1 Haemophilus somnus” lipoprotein C homologb
NP_873489.1 Sodium/proline symporter, proline permeaseb
NP_873554.1 Exodeoxyribonuclease V, beta subunitb
NP_873994.1 GTP-binding protein Erab
NP_874019.1 Cytoplasmic axial filament proteinb
NP_874161.1 50S ribosomal protein L20b
NP_874167.1 Thiamine biosynthesis protein ThiIb
NP_874218.1 DNA-directed RNA polymerase beta" subunitb
NP_872924.1 Probable pseudouridylate synthaseb
NP_873015.1 Inositol-1-monophosphataseb
NP_873352.1 DNA polymerase III subunit betab
NP_873522.1 Argininosuccinate lyaseb
NP_873683.1 DNA polymerase Ib
NP_873822.1 Putative soluble lytic murein transglycosylaseb
NP_873909.1 Inositol-5-monophosphate dehydrogenase
NP_873978.1 DNA topoisomerase IV subunit Ab
NP_874013.1 2-Oxoglutarate dehydrogenase
NP_874067.1 Type III restriction enzymeb
NP_874255.1 ATP-dependent DNA helicase RecGb
NP_874330.1 ATP-dependent protease ATP-binding subunitb
NP_873678.1 Transcriptional regulatory proteinb
NP_872770.1 RNase activity regulator protein RraAb
NP_873187.1 Opacity associated protein Ab
NP_873533.1 50S ribosomal protein L9
NP_874341.1 Hypothetical protein HD2023b
NP_872931.1 Nitrate reductase, cytochrome c-type proteinb
NP_873712.1 Protein-export membrane proteinb
NP_873322.1 Arginine ABC transporter, periplasmic-binding proteinb
NP_874304.1 50S ribosomal protein L16b
NP_874305.1 30S ribosomal protein S3b
NP_873175.1 Possible cell division proteinb
NP_873241.1 Twin arginine translocase protein Ab
NP_873417.1 Hypothetical protein HD0923b
NP_873558.1 Hypothetical protein HD1080b
NP_873615.1 Serine transporterb
NP_874095.1 Na+/H+ antiporter proteinb
NP_874189.1 Probable OM proteinb
NP_873253.1 50S ribosomal protein L33b
NP_874227.1 Putative oligopeptide transporterb
NP_874302.1 30S ribosomal protein S17b
NP_872773.1 Inorganic pyrophosphatase
NP_873718.1 Single-strand DNA-binding protein
NP_873875.1 Ribosome-binding factor Ab
NP_873990.1 Elongation factor Ts
NP_874138.1 Colicin tolerance proteinb
NP_874162.1 50S ribosomal protein L35b
NP_872836.1 S-Adenosyl-methyltransferaseb
NP_872825.1 Glucose-specific phosphotransferase system enzyme IIA componentb
NP_872882.1 Hypothetical protein HD0292b
NP_873347.1 Putative secreted proteaseb
NP_873491.1 Hypothetical protein HD1001b
NP_873542.1 Hypothetical protein HD1060b
NP_873812.1 Molybdopterin converting factor subunit 2b
NP_874081.1 Hypothetical protein HD1710b
NP_874171.1 Thioredoxin
NP_872949.1 Ferric uptake regulation proteinb
NP_873141.1 Hypothetical protein HD0600
NP_873397.1 Cytolethal distending toxin protein Ab
NP_874145.1 Cytochrome d ubiquinol oxidase, subunit Ib
NP_874229.1 Peptide deformylaseb
NP_873284.1 Mannose-specific phosphotransferase IIAB component
NP_873537.1 Probable pseudouridine synthaseb
NP_873649.1 (3R)-Hydroxymyristoyl-acyl carrier protein dehydrataseb
NP_873684.1 Outer-membrane lipoprotein carrier protein precursorb
NP_873695.1 50S ribosomal protein L25b
NP_873769.1 Thiol/disulfide interchange protein
NP_873885.1 Hypothetical protein HD1472b
NP_874309.1 50S ribosomal protein L23b
NP_874277.1 50S ribosomal protein L19b
NP_872711.1 Hypothetical protein HD0097b
NP_872838.1 Penicillin-binding protein 3b
NP_872902.1 Dipeptide transport system permease proteinb
NP_873167.1 2,3,4,5-Tetrahydropyridine-2-carboxylate N-succinyltransferase
NP_873199.1 Trigger factor
NP_873226.1 Possible TetR family transcriptional regulatorb
NP_873335.1 UDP-glucose-4-epimeraseb
NP_874007.1 Hypothetical protein HD1618b
NP_874027.1 Possible integral membrane protein of DedA familyb
NP_874105.1 30S ribosomal protein S15b
NP_874192.1 Aminoacyl-histidine dipeptidaseb
NP_874297.1 50S ribosomal protein L14b
NP_872715.1 Hypothetical protein HD0101b
NP_872816.1 Heme-binding protein Ab
NP_872842.1 UDP-N-acetylmuramoyl-l-alanyl-d-glutamate synthetaseb
NP_872976.1 Electron transport complex protein RnfC
NP_873011.1 Transcription antitermination protein NusBb
NP_873283.1 Mannose-specific phosphotransferase system IIC componentb
NP_873507.1 Probable macrolide-specific efflux proteinb
NP_873672.1 Hypothetical protein HD1219b
NP_873685.1 Ribosomal protein S6 modification proteinb
NP_873703.1 Exoribonuclease IIb
NP_873728.1 Recombination factor protein RarAb
NP_873764.1 Hypothetical protein HD1332b
NP_873846.1 Alanyl-tRNA synthetaseb
NP_873849.1 Hypothetical protein HD1432b
NP_873984.1 Pyridoxine biosynthesis proteinb
NP_874196.1 TDP-4-keto-6-deoxy-d-glucose transaminaseb
NP_874310.1 50S ribosomal protein L4b
a

Proteins are listed in order of relative abundance from greatest to least.

b

Proteins that have not been identified in previous H. ducreyi proteomics studies (39, 43).