TABLE 3.
All 13 of the tested human promoters without a predicted degenerate sitea are confirmed to contain a DNA-binding site(s) for EBNA1 based on EMSA analysis
| Chromosome | Fig.b | Gene(s) within 10 kb of promoter regionc (bidirectional) | Signal max (log2) | Predicted position P valued |
|---|---|---|---|---|
| 3 | 1 | SELK, ACTR8 | 4.64 | 2.7 × 10−6 |
| 17 | 2, 4 | FAM100B, QRICH2 | 3.73 | 6.1 × 10−7 |
| 13 | 2 | SPATA13, C1QTNF9 | 3.39 | 6.1 × 10−8 |
| 21 | 2 | CBR1, SETD4 | 2.85 | 1.0 × 10−7 |
| 8 | 2 | FBXO43, POLR2K, SPAG1 | 2.56 | 7.2 × 10−6 |
| 1 | 4 | AP4B1, DCLRE1 B | 3.98 | 2.0 × 10−7 |
| 7 | 4 | GIMAP5, GIMAP3P, hmm49583, hmm49817 | 2.92 | 4.4 × 10−6 |
| 7 | NFE2L3 | 3.95 | 2.9 × 10−6 | |
| 9 | RMI1, LOC729388, HNRPK, NIPSNAP3B | 3.71 | 2.9 × 10−6 | |
| X | hmm46563, hmm28428 | 3.47 | 2.9 × 10−6 | |
| 5 | LOC389289, LOC153684 | 3.32 | 1.7 × 10−5 | |
| 3 | MED12L, P2RY14, GPR87 | 3.02 | 4.4 × 10−5 | |
| 8 | ARHGEF10 | 2.79 | 7.5 × 10−7 |
a
The degenerate site was GRWWRYVYRYVCTDYY.
b
As shown in the figures indicated.
c
Sequences for these promoters were obtained based on reported NimbleGen ChIP-chip data and downloaded from NCBI (build 36.2).
d
Where multiple sites are predicted to align to the signal maximum, only the lowest associated position P value is reported.