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. 2009 Jan 21;83(7):3138–3149. doi: 10.1128/JVI.02073-08

FIG. 5.

FIG. 5.

Gag-specific CD8 T-cell lines are more effective than Env-specific lines in control of HIV replication. (A) Significant differences in antiviral efficacy against both R5 and X4 virus were observed between Gag-specific (n = 14) and Env-specific (n = 12) cell lines, using either an R5 virus (left panel) or X4 virus (right panel). (B) Similar significant differences in the ability to inhibit virus replication were detected when we compared Gag-specific (n = 13 for R5; n = 12 for X4) and Env-specific (n = 7 for either R5 or X4) cell lines for which the autologous viral sequences were homologous to the experimental R5 or X4 virus. (C) Antiviral efficacy against both R5 and X4 virus appeared greater for HLA B*27/B*57-restricted lines (n = 5) compared to non-HLA B*27/B*57-restricted lines (n = 21). (D) Among non-HLA B*27/B*57-restricted cell lines, we observed that Gag-specific (n = 10) responses inhibited R5 or X4 virus replication significantly better than Env-specific (n = 11) responses. Statistical comparisons were made using the Mann-Whitney test.