TABLE 2.
Reductions in viral titers observed following IFN treatment of guinea pigs
| Virus | Dose | Treatmenta | Mean peak titer in nasal washb | No. of animals with seroconversion/ total no. of animals (HI titer) |
|---|---|---|---|---|
| 1918 | 106 PFU | None | 5.3 (1) | 4/4 (160-320) |
| 106 PFU | IFN | 3.2 (3) | 4/4 (160-320) | |
| 103 PFU | None | 2.9 (3) | 4/4 (160-320) | |
| 103 PFU | IFN | 4.1 (3)** | 2/4 (80-160) | |
| H5N1 | 103 EID50 | None | 4.2 (1) | 4/4 (40-80) |
| 103 EID60 | IFN | 3.4 (3)* | 2/4 (20-40) |
a
IFN treatment was given on days −1, 0, 1, 3, 5, and 7 p.i.
b
Expressed as mean log PFU/EID50 (day of observation). *, virus was detected in only 1/4 animals; **, virus was detected in only 2/4 animals.