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. 2009 Jan 19;83(7):2803–2818. doi: 10.1128/JVI.02424-08

TABLE 5.

Hemagglutination-inhibitory activity against Pan/99 virus of sera from guinea pigs immunized with Pan/99-based live attenuated vaccine

Treatment and guinea pig Vaccine Route of challengec Titer
Preimmune Postvaccinationd Postchallengee
Live attenuated vaccine, homologous challengea
    47 PBS Inoculation i.n. 10 10 320
    48 PBS Inoculation i.n. 10 10 320
    49 PBS Exposure 10 10 320
    50 PBS Exposure 10 10 160
    51 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 320 160
    52 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 320 320
    53 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 320 320
    54 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 160 160
    55 Pan/99 HA NA:PR8 NS1-73 Exposure 10 320 320
    56 Pan/99 HA NA:PR8 NS1-73 Exposure 10 320 320
    57 Pan/99 HA NA:PR8 NS1-73 Exposure 10 160 160
    58 Pan/99 HA NA:PR8 NS1-73 Exposure 10 160 160
Live attenuated vaccine, heterologous challengeb
    59 PBS Inoculation i.n. 10 10 20
    60 PBS Inoculation i.n. 10 10 20
    61 PBS Exposure 10 10 10
    62 PBS Exposure 10 10 80
    63 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 1,280 1,280
    64 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 1,280 2,560
    65 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. <10 640 640
    66 Pan/99 HA NA:PR8 NS1-73 Inoculation i.n. 10 2,560 2,560
    67 Pan/99 HA NA:PR8 NS1-73 Exposure 10 1,280 5,120
    68 Pan/99 HA NA:PR8 NS1-73 Exposure 10 5,120 2,560
    69 Pan/99 HA NA:PR8 NS1-73 Exposure 10 1,280 2,560
    70 Pan/99 HA NA:PR8 NS1-73 Exposure 10 1,280 2,560
a

See Fig. 7.

b

See Fig. 8.

c

i.n., intranasally.

d

Postvaccination blood samples were collected 42 days after the initial vaccination dose was given.

e

Postchallenge blood samples were collected on day 17 or 18 after challenge.