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. 2009 Jan 2;29(7):1922–1932. doi: 10.1128/MCB.01907-08

FIG. 3.

FIG. 3.

P1G-MIF-expressing mice show an intermediate phenotype in skin tumorigenesis. (A) Immunohistochemical evidence of equivalent production of P1G-MIF and native MIF in skin of mifP1G/P1G and mif+/+ mice (magnification, ×400). (B) Tumor incidence in one-stage benzo[α]pyrene-induced skin tumorigenesis (n = 32 to 36 mice per group). Kaplan-Meier analysis and a log rank test yield the following: P < 0.001 for mif−/− versus mif+/+ mice; P < 0.029 for mifP1G/P1G versus mif+/+ mice; P not significant for mif−/− versus mifP1G/P1G mice. (C) Tumors per mouse in one-stage benzo[α]pyrene-induced skin tumorigenesis. Statistics using the general linear model yields the following: *, P < 0.001 for mif−/− versus mif+/+ mice, P < 0.011 for mifP1G/P1G versus mif+/+ mice, and P < 0.001 for mif−/− versus mifP1G/P1G mice.