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VHL and activin B promote changes in cell shape and invasiveness in RCC cells plated on collagen I gels. (A) Phase-contrast micrographs of indicated cell lines. (B) Invasiveness of indicated cell lines in collagen I gels at different time points (days) after plating. (C) Invasiveness of cell lines 3 days after plating when left untreated or treated with recombinant activin B (10 ng/ml) for 1 week prior to the experiment.
