FIG. 7.
Knockdown of activin B reduces growth of RCC cells in nude mice. Mice were injected with the cell lines indicated in Fig. 4. (A) Representative tumors formed 12 weeks after injection of 3 × 106 cells (arrows). (B) Increase in tumor volume of the indicated cell lines was determined over a period of 11 weeks (pool of clones neo#1 to neo#3, n = 4; clone neo#1, n = 4; pool of si1-βB#1 to si1-βB#3, n = 4; si1-βB#2, n = 4) (C) Increase in tumor volume of the indicated cell lines was determined over a period of 11 weeks (pool of neo#1 to neo#3, n = 13; pool of si2-βB#1 to si2-βB#3, n = 7). For panels B and C, 5 × 106 cells were injected.