Table 2.
Parameter | Controls (n=14) | Major Depression (n=14) |
---|---|---|
Age (years)* | 48 ± 4.3 | 49 ± 4.2 |
PMI (hours)* | 19 ± 1.7 | 22 ± 1.5 |
pH* | 6.7 ± 0.08 | 6.6 ± 0.08 |
Gender (F/M) | 3/11 | 3/11 |
Medication history a | none | n=4 (sertraline, n=2; fluoxetine, n=1; fluoxetine, paroxetine, amitriptyline, n=1) |
Comorbid diagnosis | History of alcohol dependence, n=2 | Alcohol abuse/dependence, n=2 |
History of alcohol abuse, n=1 | ||
Polysubstance abuse, n=1 | ||
Smoking | Smokers, n=4 | Smokers, n=4 |
History of smoking, n=2 | History of smoking, n=2 |
Treatment with antidepressants within 4 wk of time of death;
mean ± S.E.M; PMI, postmortem interval; F, female; M, male. The average ages, PMI, and pH values of depressed and control subjects were not statistically different.