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. Author manuscript; available in PMC: 2009 Mar 16.
Published in final edited form as: J Gen Virol. 2008 Sep;89(Pt 9):2228–2239. doi: 10.1099/vir.0.83600-0

Figure 1.

Figure 1

Summary of interactions captured in the model. Resting CD4+ T-cells (T4) become active helper T-cells (Th) via DC antigen presentation. T4 and Th cells become infected (I) and produce virus (V). Viral antigen, and T-cell help from Th promotes DC function (bottom green arrow). Immature dendritic cells (iDC) become matured (MDC) by viral antigen, and licensed (LDC) by T-cell help. LDC promote immunity (top left green arrow) by priming CD8+ T-cells to become cytotoxic T-lymphocytes (CTL). CTL promote viral control (top right green arrow) by killing infected cells (I), and via non-lytic antiviral factors. This immunogenic cycle (green arrows) is disrupted by the dual role of dendritic cells promoting infection (bottom red arrow).