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. Author manuscript; available in PMC: 2009 Mar 16.
Published in final edited form as: J Gen Virol. 2008 Sep;89(Pt 9):2228–2239. doi: 10.1099/vir.0.83600-0

Figure 6.

Figure 6

Direct failure of licensed DCs more likely contributes to HIV-1 immunopathogenesis than an indirect failure of CD4+ T-cell help. (A) Two hypotheses of DC dysfunction: Loss of CD4+ T-cell help could indirectly cause DC failure to prime CTLs (Hypothesis 1). This is represented in the model by decrease in parameter λ. Alternatively, the virus could directly impair DC function (Hypothesis 2). This is represented in the model by decrease in parameter r8L. (B) Global sensitivity analysis using the eFAST method shows that CTL priming by licensed DCs (r8L) is a significantly more sensitive control point of the system, favouring Hypothesis 2.