Table 1.
Model simulation values compared to non-human primate experimental data and published human clinical data in lymph node
Infection state / Model timepoint |
Count | Model simulation | Non-human Primate |
Human clinical data(Haase, 1999) |
---|---|---|---|---|
no infection / day 0 | total CD4+ T-cell | 3.5 × 108 | 3.7 × 108* | 2.9 × 108 |
chronic / day 300 | total CD4+ T-cell | 8.6 × 107 | 10.7 × 107* | 6.7 × 107 |
acute / day 6 | infected cell | 2.5 × 106 | 1.7 × 106 | 7.1 × 105 |
chronic / day 300 | infected cell | 8.2 × 105 | 6.4 × 105 | 5.7 × 104 |
acute / day 6 | virus | 2.0 × 109 | > 108 | |
chronic / day 300 | virus | 8.3 × 108 |
= this value was calculated from total T-cell count and the CD4:CD8 ratio from (Biancotto et al. 2007)