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Single-molecule experiments under high cisplatin concentration (770 μM). (A) A typical variation of the DNA extension. The external force exerted on the DNA was ∼1 pN. The sharp decrease corresponded to the time of drug flow. (B) Control experiment where DNA was kept stretched by a high force (20 pN) close to its contour length. Although 770 μM cisplatin was added, DNA hardly shortened.
