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(A) Schematic illustration of the ligand binding to nucleotides opposite an AP site in a DNA duplex. For the detection of SNPs, an AP site-containing probe DNA is hybridized with a target DNA so as to place the AP site towards a target nucleotide, by which a hydrophobic binding pocket is provided for aromatic ligands to bind to target nucleotide. (B) Structures of the series of 2-amino-1,8-naphthyridines examined in this work.
