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. 2009 Mar 25;4(3):e4948. doi: 10.1371/journal.pone.0004948

Figure 1. MV infection induces a strong activation of the immune response in CD150 transgenic mice.

Figure 1

CD150 transgenic mice and nontransgenic littermates (control) were inoculated i.n. with MV or medium (uninfected). Spleens were harvested 13 dpi and cells were analyzed by flow cytometry. (A) Expression of MV hemagglutinin (H) antigen on the surface of spleen cells from uninfected (grey line) and MV-infected (black line) CD150 transgenic mice, gated on CD19+ (B cells) or CD3+ (T cells) cells. Numbers are percentages of cells expressing MV H antigen in infected conditions. (B) Staining for CD4+ and CD8+ T cells and (C) CD19+ B cells, among analyzed splenocytes. Results are representative of 8 different experiments, each involving 3–6 mice. Differences between CD150 transgenic infected mice and the other groups were statistically significant (p<0.05, Student t-test).