Figure 6. Longevity of the HIV-1 envelope glycoprotein intermediate at room temperature after activation by sCD4 or 191.

(A) The decay of HR1 groove exposure for cell-surface–expressed YU2 and AD8 envelope glycoproteins is compared after pulse activation with 191 (360 µM) or sCD4 (40 µg/ml, 0.8 µM). (B) The decay of the ability to infect CD4⁻CCR5⁺ Cf2Th cells after pulse activation with 191 or sCD4 is compared.