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. 2009 Jan 19;18(7):1332–1342. doi: 10.1093/hmg/ddp033

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Methylation microarray analysis of 17 genes reveals methylation variability in repetitive elements. (A) The distance from each of the MVP to the nearest repetitive element was calculated for each of the 181 distinct MVPs revealing 44% of peaks within 100 bp of the nearest repetitive element. Random placement of 181 simulated MVP peaks reveals a distribution containing only 26% of peaks within 100 bp of the nearest repetitive element. Kolmogorov–Smirnov test was used to determine the significance of the difference in distribution. (B) The smoothed average of MATScores (±2 SD in red) for genes aligned at the TSS reveals periodic increase in methylation variability across the first 10 kb (of genes >10 kb) or across the first 5 kb (of shorter genes, median 4.5 kb).