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. 2009 Jan 19;18(7):1332–1342. doi: 10.1093/hmg/ddp033

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Methylation of LINE1, ATM CpG island, mvp2a and mvp2b in 190 bilateral breast cancer cases compared with 190 controls. (A) Schematic of the genomic location of the ATM CpG island (CGI) at the TSS and at mvp2a and mvp2b within the second intron of ATM. (B) Pyrosequencing-based methylation analysis of 190 bilateral breast cancer cases compared with 190 matched controls reveals no methylation in the promoter CpG island and significant inter-individual methylation variability in the intronic mvp2a and mvp2b. Significant hypermethylation of mvp2b is detected in bilateral breast cancer cases compared with controls (P = 0.0017, Wilcoxon signed rank sum test). Box and whisker plots represent median (centre line), inter-quartile range (box) and 95th percentiles (whisker), and samples outwith this range are represented as points. (C) Kernel density plot of methylation values in cases (solid line) compared with controls (dotted lines) showing overlapping distributions for LINE1, ATM CpG island and ATM mvp2a and a skewed distribution of methylation at ATM mvp2b in the cases.