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Chimeric CHRNA1 exon P3A minigene for screening of chemical compounds. CHRNA1 exon P3A and its flanking introns are inserted after position 834 (arrowhead) of the firefly luciferase cDNA. Skipping of exon P3A should generate an intact luciferase molecule, whereas inclusion of exon P3A should abrogate it. The hnRNP H-binding ‘TGGG’ motif is underlined.
