Figure 1.

Bardet-Biedl syndrome mice are resistant to leptin. (A) Serum leptin levels of wild-type and calorie-restricted (CR) Bbs2^−/− (2KO), Bbs4^−/− (4KO) and Bbs6^−/− (6KO) mice. Serum leptin level of normally fed Bbs2 null mice was shown for comparison (n = 4–16). (B, C) Bbs2, Bbs4 and Bbs6 null mice with normal circulating leptin levels are still resistant to the weight- and appetite-reducing action of leptin. Changes in body weight and food intake were measured 24 h after ICV leptin administration (n = 5–16). Data are mean ± SEM. *P < 0.05 compared with wild-type mice; ^†P < 0.05 versus vehicle.