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. 2009 Jan 15;18(7):1323–1331. doi: 10.1093/hmg/ddp031

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Bardet-Biedl syndrome (BBS) proteins are required for LepRb trafficking. (A) Alteration of the LepRb trafficking in BBS1- and BBS2-depleted cells. ARPE-19 cells were transfected with FLAG–LepRb together with scrambled (control), BBS1 or BBS2 RNAi constructs. Localization of LepRb (green) and TGN46 (red) was probed by indirect immunofluorescence microscopy. Merged images with DAPI staining (blue; nuclei) are shown. (Scale bars: 10 µm). (B) Percentage of transfected cells (determined by FLAG immunofluorescence) with large vesicles. Values are average of three experiments and a minimum of 120 cells was counted in each experiment. Data are mean ± SEM.