Fig. 1.

The microbione exerts a broad effect on mammalian biochemistry. (Upper) The experimental workflow for the metabolomics studies performed. (Lower) Major differences are observed in the profiles of GF and conv plasma obtained employing + ESI. PCA analysis of the profiling data from XCMS (Left) shows an excellent separation between sample groups. As shown in the Venn diagram (Right), most species are observed in both GF and conv samples, but a significant number are unique to a given sample set, with ≈3-fold more ions unique to the conv sample.