Fig. 1.

Oligomeric Aβ is present in the dense core of amyloid plaques and in a halo surrounding the core. (A) NAB61 antibody conjugated to Alexa Fluor 594 (red) applied topically in vivo shows oligomeric Aβ surrounding dense plaques (labeled with methoxy XO4; blue). (B) Postmortem staining of dense plaques by using methoxy XO4 (blue) and oligomeric Aβ by using NAB61 antibody (red) confirms that oligomeric Aβ is found in the core of plaques and in an area surrounding the core. (Scale bar: 10 μm.)