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. 2008 Nov 19;10(6):R136. doi: 10.1186/ar2554

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Copyright © 2008 Du et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of T-614 on cytokine levels in CIA rats. Rats were orally treated with different doses of T-614, nimesulide, MTX and vehicle, beginning on day 12 after the immunization with CIA until day 36. (a) Effects of T-614 on mRNA levels of IFN-γ, IL-4 and IL-17 in lymph node and PBMCs from CIA rats. (b) Effects of T-614 on serum levels of TNF-α, IL-1β, IL-6 and IL-17 in the CIA rats. CIA, collagen-induced arthritis; IFN, interferon; IL, interleukin; LN, lymph node; MTX, methotrexate; PBMC, peripheral blood mononuclear cell.